In this announcement, the Institute of Education Sciences invites applications for research projects that will contribute to its Special Education Research and Development Center program. For the FY 2012 Special Education Research and Development Center competition, the Institute invites applications for four Special Education Research and Development Centers: (1) Special Education Research and Development Center on School-Based Interventions for Secondary Students with Autism Spectrum Disorders, (2) Special Education Research and Development Center on Reading Instruction for Deaf and Hard of Hearing Students, (3) Special Education Research and Development Center on Interventions for Families of Students with Autism Spectrum Disorders, and (4) Special Education Research and Development Center on Interventions for Families of Students with Emotional and Behavioral Disorders.