Moderation and Non-compliance in Multi-Site Trials with Measurement Error and Missing Data

The purpose of this grant is to produce a general statistical framework and an associated set of statistical guidelines and tools for studying such impact variability. The project will address three major design issues: 1) A treatment effect may be moderated by covariates that are measured with error; 2) The covariates and outcome, whether continuous or discrete, may be only partially observed; and 3) Compliance to treatment assignment may be imperfect. The project will also extend these issues to RCTs in which a treatment effect may be random and moderated by covariates.