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Grant Closed

Moderation and Non-compliance in Multi-Site Trials with Measurement Error and Missing Data

NCER
Program: Statistical and Research Methodology in Education
Program topic(s): Core
Award amount: $899,995
Principal investigator: Yongyun Shin
Awardee:
Virginia Commonwealth University
Year: 2021
Award period: 4 years (03/01/2021 - 02/28/2025)
Project type:
Methodological Innovation
Award number: R305D210022

Purpose

The purpose of this grant is to produce a general statistical framework and an associated set of statistical guidelines and tools for studying such impact variability. The project will address three major design issues: 1) A treatment effect may be moderated by covariates that are measured with error; 2) The covariates and outcome, whether continuous or discrete, may be only partially observed; and 3) Compliance to treatment assignment may be imperfect. The project will also extend these issues to RCTs in which a treatment effect may be random and moderated by covariates.

Project Activities

The research team will develop the statistical analysis by estimating the parameters of the theoretical model via maximum likelihood from incomplete data using adaptive Gauss-Hermite Quadrature. They will extend this approach to multi-site trials in which each can be regarded as possessing a unique set of principal strata.

People and institutions involved

IES program contact(s)

Charles Laurin

Project contributors

Stephen Raudenbush

Co-principal investigator

SubAwardee(s)

University of Chicago

Products and publications

  • HLM with Missing Data: Software for Estimating Hierarchical Models from Incomplete Data 
    • Available at https://sph.vcu.edu/about/portfolio/details/yshin/ 
  • HGLM with random coefficients, moderation and noncompliance
    • Freely download from the publicly accessible GitHub page: https://github.com/sunx63/CACE 
  • HLM with level‐2 interaction effects of site‐level continuous covariates: Bayesian  estimation using a Gibbs sampler 
    • The implementation  code in R is freely available from the publicly accessible GitHub page:  https://github.com/shind10/GSExact 

Publications:

Shin, D., Shin, Y. and Hagiwara, N. (2025). Bayesian Estimation of Hierarchical Linear Models from Incomplete Data: Cluster‐Level Interaction Effects and Small Sample Sizes, Statistics in Medicine, 44(10-12), e70051, https://doi.org/10.1002/sim.70051.  

Shin, Y., & Raudenbush, S. W. (2024). Maximum Likelihood Estimation of Hierarchical Linear Models from Incomplete Data: Random Coefficients, Statistical Interactions, and Measurement Error. Journal of Computational and Graphical Statistics, 33(1), 112-125.

Sun, X., Shin, Y., Lafata, J.E., and Raudenbush, S.W. (2024). Variability in Causal Effects and Noncompliance in a Multisite Trial: A Bivariate Hierarchical Generalized Random Coefficients Model for a Binary Outcome. Statistics in Medicine, 43(28), 5353-65, https://doi.org/10.1002/sim.10229. 

Questions about this project?

To answer additional questions about this project or provide feedback, please contact the program officer.

 

Tags

Data and AssessmentsEducation TechnologyMathematics

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Questions about this project?

To answer additional questions about this project or provide feedback, please contact the program officer.

 

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