Contract Open

Sci-Quest: An Interactive Guided Hero's Journey Through the Scientific Method

NCER

Program: Small Business Innovation Research

Award amount: $250,000

Project director: Vicki Nienaber-Meadows

Awardee:

Zenobia Therapeutics, Inc.

Year: 2025

Award period: 8 months (09/12/2025 - 05/11/2026)

Project type:

Phase I Development

Contract number: 91990025C0082

Purpose

The purpose of this project is to develop and evaluate a prototype of Sci-Quest, an AI-enhanced, gamified science learning platform designed to support high school students in communities with economic challenges and limited exposure to biotechnology careers. The goal is to increase science engagement, strengthen literacy and comprehension, and build awareness of high-wage STEM opportunities. We are focused on regions like San Diego's Promise Zone and border communities, where biotechnology industries thrive just miles from schools that remain disconnected from these fields. Built as an extension of the XplorStem Academy platform, Sci-Quest transforms traditional science curriculum into an interactive "Hero's Journey" aligned with the scientific method. AI-driven writing support and adaptive vocabulary games aim to address language and literacy barriers while augmented skills labs teach hands-on laboratory techniques. The platform follows Universal Design principles to ensure accessibility, cultural relevance, and long-term adaptability for classrooms serving diverse student populations.

Project Activities

Zenobia Therapeutics (DBA XplorStem) will design and build the Sci-Quest prototype around a proven digestion lesson and hands-on laboratory, allowing for direct comparison with prior data from its predecessor, XplorStem-Academy. Development will include a front-end redesign into a Hero's Quest format and integration of progressive AI components such as real-time writing scaffolding using Natural Language Processing, adaptive vocabulary games, and virtual coaching during hands-on labs. The platform will follow Universal Design principles to support diverse learners, including English Language Learners and students with limited literacy. A back-end database overhaul will support modular content integration, secure student performance tracking, and long-term scalability.

The pilot will be conducted with three school districts in San Diego County's Promise Zone and border region that serve communities with economic barriers and limited exposure to biotechnology careers. It will involve three experienced science teachers and approximately 150–280 students. Iterative classroom testing will guide refinement of the user experience, AI functionality, and data infrastructure. The project team includes STEM coordinators, CTE project leaders, and district administrators, positioning the platform for future implementation and broader national adoption across high schools with emerging biotech programs.